Why Leeches?

Substances in Leech’s Saliva

 1. Hirudin : This is a peptide secreted by the leech’s salivary glands that is injected into the wound during sucking to prevent the blood coagulating. Hirudin is a potent anticoagulant that inhibits the conversion of fibrinogen to fibrin — preventing blood from clotting. Anti-coagulant, much more powerful then pharmaceutical blood-thinners such as plavix, or coumadin. Hirudin works with vasodilator compounds to increase blood flow to an аrеа.
leeches 12.. Orgalese: Brings micro-circulation back and creates and restores micro capillaries

3. Calin : which binds to collagen and neutralises its capacity to induce clotting. Inhibits blood coagulation and inhibits colagin and mediated platelet aggregation.

4. Destabilase : a monomerizing activity which is to solve vibrind ( the result of gore ) This enzyme therefore gives leeches the ability to lyse clots; this is therefore no longer simply an anticoagulant process but a fibrinolytic supply process.

5. Hirustasin : functioning as protein solven agent to improve digestion.

6. Bdellins :  Anti-inflammatory effects plus effects the skin :  can reduce skin inflammation, swollen skin, and  itchy skin.

7. Hyaluronidase : an antibiotic to prevent infection. An enzyme that splits hyaluronic acid and so lowers its viscosity and increases thepermeability of connective tissue and the absorpstion of fluids.  This is what they use in the cosmetics and creams.

8. Anesthetic Substance : the anesthetic for certain area in the body (local anesthetic).

9. Triptase Inhibitor : a substance produced in swollen or allergic area.

10. Egllins :  Anti-inflammatory effects plus effects the skin (more than Bdellins) the anti-swollen substance.

11. Xa inhibitor factor :  anti-coagulant, by forming equimolar complexes

12. Histamine-like substance : maximize the arteri tracts to help better blood flow. Vasodilator, increases the inflow of blood at the bite site

13.  Collagenase This enzyme splits the collagen chain. And collagen is involved in activation of platelet aggregation.

14.  Apyrase This is a phosphohydrolase that hydrolyses ATP and ADP. It is a potent anti-platelet aggregant.

15.  A prostaglandin This substance acts like prostacyclin and its analogues and has an effect on platelet aggregation by preventing the attachment and diffusion of platelets on collagen and activating the adenyl-cyclase of the platelet membranes, thereby generating an anti-aggregant substance.

16. Lipase and esterase The salivary secretions of Hirudo medicinalis have a lipolytic capacity in order to play a digestive role with respect to the ingested blood. Two enzymes are responsible for this capacity: a lipase and a cholesterol-esterase.

17.  Hormones : cortisol, progesterone, testosterone, estradiol and dehydroepiandrosterone

18. Endorphins: Natural Pain and Stress Fighters

19. Neurotransmitters:are the brain chemicals that communicate information throughout our brain and body.

 serotonin –   Adequate amounts of serotonin are necessary for a stable mood and to balance any excessive excitatory (stimulating) neurotransmitter firing in the brain.

dopamine- is a special neurotransmitter because it is considered to be both excitatory and inhibitory.  Dopamine helps with depression as well as focus, which you will read about in the excitatory section.